First off, of course, is to ensure both you and your wife have adequate life/disability insurance coverage, your wills and powers-of-attornies are in place, you're saving for long-term expenditures like vehicle replacement and kids' college funds, and you have a fully-funded emergency fund.
After that, I'd aim for saving 15-20% of your pre-tax income, which at your income would be around $500-$675 every two weeks.
I'd first direct it into a TFSA and invest it in a handful of low fee index funds (such as TD Waterhouses e-series) spread across several markets (TSX, DJ, S&P 500, and maybe one overseas market).
Once you've maxxed our yours and your wife's TFSAs, direct the rest into your RRSPs, in the same vehicles (low-fee, broad market index funds).
At that savings rate, you will not likely ever hit your RRSP contribution limit (unless your employer has a pension you've not mentioned, in which case the pension adjustment would come into play, adjusting your RRSP contribution limit downward accordingly), but if you do, invest the rest in an unregistered investment brokerage account, still in the same things.
Fantastic info! The wills are in place and we are going to do up the POA right away as well.
We have lots of room in both the TFSA and RRSP, I don't see hitting the limit in the RRSP side either based on the numbers you came up with. I still don't understand why the guide is 15% pre tax income... I don't get to spend my pre tax income, only after tax. Still, $500 every two weeks seems reasonable which is about 15% of my current pre tax.
I also have an RBC Dominion Investor who wants to take on portfolio and he's done great work for my in-laws. I would leave the asset mix up to him as long as his fees aren't crazy which he claims they are not.