I set up a Wesabe account last year and was really impressed by it. I haven't used it much lately, though, since at the time it wasn't really far enough along in terms of features to be a replacement for Quicken for me. Plus all my historical data in Quicken is key, of course.
The social elements are very cool, including the ability to tag transactions, enter in the "smart name" once, and have all that data remembered for the next time - and to learn from the community.
Marc and his team are great, and definitely listen to input. In fact, one of my earlier suggestions on the uploader was to allow column header sorting for the Account / Upload Type / Last Upload columns, and I just upgraded to the latest version, and am pleased to see that in there.
Ever try making a suggestion to Intuit? You certainly won't have the same luck.